Cleaning-in-Place for Pharma Applications
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| CIP for Pharmaceutical Process Plants |
Clean-in-Place (CIP) and Sterilize-in-Place (SIP) systems are designed to both automate essential cleaning and disinfection processes and remove the need for time-consuming dis-assembly and assembly work.
Process optimization depends on efficient, effective cleaning. Clean-in-Place (CIP) systems can be incorporated into all the equipment for the pharmaceutical industry, including both solid and liquid dosage formulation systems. Automating the cleaning process ensures repeat-ability, allows validation and minimizes downtime.
Compliant Cleaning Solutions and Cost Benefits
The most effective way to implement CIP technology is to design it into a process. Incorporating spray systems, tank cleaners, nozzles and seals to automate the cleaning process.
Automating the cleaning cycle essentially converts batch pharmaceutical processes into a continuous operation of production and cleaning cycles. The advantages of CIP include :
- reduced cleaning cycle times
- optimized use of detergent and water
- eliminates manual cleaning.
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| Flexim F601 for CIP Flow Rate measurement |
At the heart of the CIP system is needs an advanced Wash Liquid Preparation Unit, which handles all filtering, preheating, mixing and pumping of water, detergents and demineralized water.
It provides continuous monitoring and control of cleaning parameters, including :
1. flow rate, using ultrasonic flowmeter clamp-on type where they provide proper sanitary standard, for example Flexim Fluxus Series F601
2. detergent concentration,
3. temperature and,
4. wash time for full process validation.